uBlock has been my favourite web browser extension for years, removing all ads including video ads in YouTube for example.
Firefox and Safari are essentially your only options if you don't want a chromium based browser. Firefox is the only one of those that supports adblocking at the level uBlock Origin operates.
For Brave, Vivaldi, Opera GX, Edge etc, to continue to support uBO, they would need to maintain a fork of Chromium that supports Manifest v2 and it's likely that Google will continue to merge anti-user privacy stuff into Chromium that makes supporting v2 untenable at some point in the future.
Quoting uBlock official documentation:
uBlock works best on Firefox.
This year, researcher David Buchanan tried to implement parallel decoding using the iDOT information. During development, he made a simple programming mistake and ended up making a wonderful discovery. He could create a PNG file with platform-dependent rendering. It looked one way on Windows, Linux, Firefox, and Chrome, and a different way on a Mac with default Apple applications, like the Safari web browser. (He found that Apple had implemented the same bug!) Buchanan provided two sample pictures (Hello World and computers) to demonstrate this per-platform rendering. It didn't take long for other people to use his code and generate other examples. Many of these images were uploaded to FotoForensics: